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8-Bromo-cGMP

PKG activator
 
BML-CN205-0010 10 mg 66.00 USD
 
BML-CN205-0050 50 mg 270.00 USD
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Replaces Prod. #: ALX-480-006

A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets.

Product Specification

Formula:C10H10BrN5O7PNa
 
MW:446.1
 
CAS:51116-01-9
 
Purity:≥96% (HPLC)
 
Identity:Determined by ESI-MS and UV/VIS.
 
Appearance:White to off-white powder
 
Solubility:Soluble in water (25mg/ml) or aqueous buffers. Sparingly soluble in methanol (4mM). Insoluble in DMSO, dimethyl formamide and 96% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-CN205
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Product Literature References

Nitric oxide in skeletal muscle: L. Kobizik et al.; Nature 372, 546 (1994), Abstract;
Nitric oxide. More jobs for that molecule: S. Snyder; Nature 372, 504 (1994), Abstract;
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton et al.; Eur. J. Neurosci. 6, 1528 (1994), Abstract;
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane et al.; Biochem. Biophys. Res. Commun. 165, 708 (1989), Abstract;
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.G. Francis et al.; Mol. Pharmacol. 34, 506 (1988), Abstract;
Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments: A.L. Zimemmerman et al.; PNAS 82, 8813 (1985), Abstract;
Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP: R.M. Rapoport et al.; PNAS 79, 6470 (1982), Abstract;
Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP: K. D. Schultz et al.; Naunyn-Schmiedebergs Arch. Pharmacol. 306, 1 (1979), Abstract;
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer Jr. & J.P. Miller; Life. Sci. 14, 1019 (1974), Abstract;

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