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MDL-12,330A

Adenosine receptor inhibitor
 
BML-CN145-0005 5 mg 65.00 USD
 
BML-CN145-0025 25 mg 264.00 USD
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Replaces Prod. #: ALX-270-080

Adenylate cyclase inhibitor (IC50=250 µM).

Product Specification

Alternative Name:cis-N-(2-Phenylcyclopentyl)azacyclotridec-1-en-2-amine . HCl
 
Formula:C23H36N2 . HCl
 
MW:377
 
CAS:40297-09-4
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (3mg/ml), DMSO (10mg/ml, slightly warm), 100% ethanol (>10mg/ml) and hot 0.1N HCl (0.5mg/ml); insoluble in 0.1N NaOH.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling: P. Ivonnet, et al.; Br. J. Pharmacol. 172, 173 (2015), Abstract; Full Text
Melatonin biosynthesis in cultured chick retinal photoreceptor cells: calcium and cyclic AMP protect serotonin N-acetyltransferase from inactivation in cycloheximide-treated cells: A.L. Alonso-Gomez & P.M. Iuvone; J. Neurochem. 65, 1054 (1995), Abstract;
Tonic adenosine A2A receptor activation modulates nicotinic autoreceptor function at the rat neuromuscular junction: P. Correia-de-Sa & J.A. Ribeiro; Eur. J. Pharmacol. 271, 349 (1994), Abstract;
Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536: C. Lippe & C. Ardizzone; Comp. Biochem. Physiol. 99, 209 (1991), Abstract;

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