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SQ 22536

Adenylate cyclase inhibitor
BML-CN140-0005 5 mg 96.00 USD
BML-CN140-0025 25 mg 377.00 USD
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Replaces Prod. #: ALX-480-060

SQ 22536 is a cell-permeable adenylate cyclase inhibitor. It inhibits cAMP production induced by prostaglandin E1 in platelet lysates (IC50=82 µM) and in intact platelets (IC50=1 µM). It has been successfully employed as a probe for the involvement of adenylate cyclase in a variety of receptor systems including those for prostaglandins and neurotransmitters. ReducesPGE2-induced inhibition of O2- production.

Product Specification

Alternative Name:9-THF-Ade
Purity:≥99% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in water (25mg/ml) or DMSO (50mM with warming).
Long Term Storage:-20°C
Use/Stability:Stock solutions are stable for up to 3 months at -20°C.
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Product Literature References

Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney: B. Kalbe, et al.; Arch. Biochem. Biophys. 610, 8 (2016), Application(s): Calcium imaging, HK-2 cells, Abstract;
Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling: P. Ivonnet, et al.; Br. J. Pharmacol. 172, 173 (2015), Abstract; Full Text
Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils: E. Talpain et al.; Br. J. Pharmacol. 114, 1459 (1995), Abstract;
Relaxation and inhibition of contractile response to electrical field stimulation by Beraprost sodium in canine airway smooth muscle: J. Tamaoki et al.; Prostaglandins 45, 363 (1993), Abstract;
cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons: B.A. Goldsmith & T.W. Abrams; PNAS 89, 11481 (1992), Abstract;
Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons: W.X. Shi & B.S. Bunney; J. Neurosci. 12, 2433 (1992), Abstract;
Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536: C. Lippe & C. Ardizzone; Comp. Biochem. Physiol. C. 99, 209 (1991), Abstract;
Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536): E. Fabbri et al.; J. Enzyme. Inhib. 5, 87 (1991), Abstract;
Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenylyl cyclase: B.A. Goldsmith & T.W. Abrams; PNAS 88, 9021 (1991), Abstract;
Adenylate cyclase system is essential for long-term facilitation at the crayfish neuromuscular junction: D. Dixon et al.; J. Neurosci. 9, 4246 (1989), Abstract;
Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives: D. Harris et al.; J. Cyclic Nucleotide Res. 5, 125 (1979), Abstract;

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