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Sp-5,6-Dichloro-cBIMPS

PKA activator
 
BML-CN120-0001 1 mg 233.00 USD
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Replaces Prod. #: ALX-480-047

A cAMP analog which is a potent and specific activator of cAMP-dependent protein kinase. It is cell permeable and is not significantly hydrolyzed by type I, II or III phosphodiesterases. It may be used to distinguish the cAMP- versus the cGMP-mediated signal transduction pathways. Surpasses the widely used but problematic dibutyryl-cAMP (Prod. No. BML-CN125) or 8-CPT-cAMP (Prod. No. BML-CN130).

Product Specification

Formula:C12H10N2O5PSCl2 . Na
 
MW:419.2
 
Source:Synthetic.
 
CAS:120912-54-1
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (167 mM), dimethyl formamide (167 mM), 96 % ethanol (167 mM), methanol (25 mM), water (25 mM) and aqueous buffers such as phostphate buffered saline (pH 7.4; 1.4 mM), 25 mM TRIS (pH 7.4-; 25 mM), 25 mM HEPES (pH 7.2; 35.7 mM) or Na2HPO4.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Changes of IZUMO1 in bull spermatozoa during the maturation, acrosome reaction and cryopreservation: M. Fukuda, et al.; Theriogenology 86, 2179 (2016), Application(s): Treatments for induction of the acrosome reaction, Abstract;
Involvement of cyclic AMP-dependent unique signaling cascades in the decrease of serine/threonine-phosphorylated proteins in boar sperm head: A. Isono, et al. ; Theriogenology 85, 1152 (2016), Application(s): Incubation of spermatozoa for induction of acrosome reaction, Abstract;
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium: P. Schaap et al.; J. Biol. Chem. 268, 6323 (1993), Abstract;
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al.; Biochem. J. 279 ( Pt 2), 521 (1991), Abstract;

Related Products

Dibutyryl-cAMP 

PKA activator
16980-89-5, ≥98% (HPLC) | Print as PDF
 
BML-CN125-0030 30 mg 61.00 USD
 
BML-CN125-0100 100 mg 120.00 USD
Do you need bulk/larger quantities?
 

8-CPT-cAMP 

PKA activator
93882-12-3, Synthetic., ≥96% (HPLC) | Print as PDF
 
BML-CN130-0020 20 mg 65.00 USD
 
BML-CN130-0100 100 mg 264.00 USD
Do you need bulk/larger quantities?
 

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