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8-Bromo-cAMP

PKA activator
 
BML-CN115-0010 10 mg 55.00 USD
 
BML-CN115-0050 50 mg 173.00 USD
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Replaces Prod. #: ALX-480-007

A cell-permeable cAMP analog which is more resistant to phosphodiesterases than cAMP and which preferentially activates cAMP-dependent protein kinase (PKA). Has increased metabolic stability and membrane permeability comapred with cAMP.

Product Specification

Formula:C10H10BrN5O6P . Na
 
MW:430.1
 
CAS:76939-46-3
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR, 31P-NMR, ESI-MS and UV.
 
Appearance:White to grey powder
 
Solubility:Soluble in water (100mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
480-007
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480-007

Product Literature References

Hormone-induced 14-3-3γ adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells: Y. Aghazadeh et.al; J. Biol. Chem. 287, 15380 (2012), Application(s): Activation of cAMP-dependent protein kinase (PKA)., Abstract; Full Text
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3’,5’-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg et al.; Biochem. J. 279 , 521 (1991), Abstract;
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs: Y.-J. Hei et al.; Mol. Pharmacol. 39, 233 (1991), Abstract;
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer Jr. & J.P. Miller; Life. Sci. 14, 1019 (1974), Abstract;

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