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2',5'-Dideoxyadenosine

Adenylate cyclase inhibitor
 
BML-CN110-0005 5 mg 109.00 USD
 
BML-CN110-0025 25 mg 432.00 USD
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Replaces Prod. #: ALX-480-049

A useful, cell-permeable inhibitor of adenylate cyclase (ID50=250µM). Inhibits growth and causes cell differentiation (1.5µM) in K562 cells.

Product Specification

Formula:C10H13N5O2
 
MW:235.2
 
CAS:6698-26-6
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (20mg/ml at 50°C) or DMSO (30mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Solutions are stable up to 3 months when stored at -20°C
 
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Product Literature References

Erythroid differentiation and growth inhibition of K562 cells by 2’,5’-dideoxyadenosine: synergism with interferon-alpha: K. Ogawa et al.; Leuk. Res. 19, 749 (1995), Abstract;
Direct inhibitory effect of neurotensin on isolated gastric smooth muscle cells of guinea pig via the cyclic GMP system: Y. Chijiiwa et al.; Digestion 54, 135 (1993), Abstract;
Isoproterenol antagonistic effect of 2’,5’-dideoxyadenosine in the isolated perfused guinea-pig heart: M. Hartmann & J. Schrader; J. Mol. Cell. Cardiol. 25, 331 (1993), Abstract;
I. BAggioni ; Am. J. Hypertens. 6, 1475 (1992),
Inhibition of adenylate cyclase attenuates adenosine receptor-mediated relaxation in coronary artery: M.H. Sabouni et al.; J. Pharmacol. Exp. Ther. 259, 508 (1991), Abstract;
Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs: S.T. Holgate et al.; PNAS 77, 6800 (1980), Abstract;

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