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4,4-Pentamethylenepiperidine . HCl

M2 proton channel inhibitor
 
BML-CM128-0050 50 mg 82.00 USD
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A novel member of the spiro-piperidine class of M2 proton channel inhibitors similar to BL-1743. Displays increased potency (IC50=0.92µM) compared with amantadine.

Product Specification

Alternative Name:3-Azaspiro[5.5]undecane . HCl
 
Formula:C10H19N . HCl
 
MW:153.2 . 36.5
 
CAS:180-44-9
 
Purity:≥97% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (>25mg/ml), DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus: J. Wang, et al.; J. Am. Chem. Soc. 131, 8066 (2009), Abstract;
Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus: Q. Tu, et al.; J. Virol. 70, 4246 (1996), Abstract;

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