4,4-Pentamethylenepiperidine . HCl

M2 proton channel inhibitor



BML-CM128-0050	50 mg	72.00 USD

A novel member of the spiro-piperidine class of M2 proton channel inhibitors similar to BL-1743. Displays increased potency (IC₅₀=0.92µM) compared with amantadine.

Product Specification

Alternative Name:	3-Azaspiro[5.5]undecane . HCl

Formula:	C₁₀H₁₉N . HCl

MW:	153.2 . 36.5

Purity:	≥98% (TLC)

Appearance:	White solid.

CAS:	180-44-9

Solubility:	Soluble in water (>25mg/ml), DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).

Long Term Storage:	+20°C

Use/Stability:	Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.

Hazard:	HARMFUL.

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Product Literature References

Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus: J. Wang, et al.; J. Am. Chem. Soc. 131, 8066 (2009), Abstract;

Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus: Q. Tu, et al.; J. Virol. 70, 4246 (1996), Abstract;