Mdivi-1

Inhibitor of mitochondrial division



BML-CM127-0010	10 mg	74.00 USD

BML-CM127-0050	50 mg	297.00 USD

Mdivi-1 is a selective inhibitor of mitochondrial division in yeast and mammalian cells which acts via inhibiting the mitochondrial division dynamin. In cells, Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 causes the rapid (<5 min) reversible and dose-dependent formation of net-like mitochondria in wild-type cells with an IC₅₀= ~10µM. In yeast, time-lapse fluorescence microscopy revealed no detectable mitochondrial division after treatment with Mdivi-1.

Formula:	C₁₅H₁₀Cl₂N₂O₂S

MW:	353.2

Purity:	≥98% (TLC)

Appearance:	White solid.

CAS:	338967-87-6

Solubility:	Soluble in DMSO (25mg/ml).

Long Term Storage:	-20°C

Background / Technical Information:	Please click here for the comprehensive product data sheet.

Please mouse over

Product Literature References

Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization: A. Cassidy-Stone et al.; Dev. Cell 14, 193 (2008), Abstract;