Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Icilin

TRPM8 activator
 
BML-CM126-0010 10 mg 87.00 USD
 
BML-CM126-0050 50 mg 349.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-420-037

Cooling agent. Strongly activates TRPM8 (IC50=0.2µM), cold menthol receptor 1 (CMR1, IC50=0.36µM), a nonselective, cold-activated cation channel and TRPA1 (at 10- to 100-fold higher concentration). Induces currents in TRPM8 expressing HEK 293 cells (EC50=0.36mM) more potently than menthol (Prod. No. ALX-420-042) or low temperatures. Activates TRPM8 with variable latency, followed by extensive desensitization provided calcium is present. The effects of icilin can be impacted by both pH and cytosolic calcium levels.

Product Specification

Alternative Name:AG 3-5, 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone
 
Formula:C16H13N3O4
 
MW:311.3
 
CAS:36945-98-9
 
Purity:≥97% (TLC)
 
Appearance:Light yellow to orange solid.
 
Solubility:Soluble in DMSO (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
bml-cm126
Please mouse over
bml-cm126

Product Literature References

Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain: C.J. Proudfoot, et al.; Curr. Biol. 16, 1591 (2006), Abstract;
Icilin activates the {delta}-subunit of the human epithelial Na+ channel.: H. Yamamura; Mol. Pharmacol. 68, 1142 (2005), Abstract;
Sensing with TRP channels: T. Voets, et al.; Nat. Chem. Biol. 1, 85 (2005), Review, Abstract;
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay: H.J. Behrendt, et al.; Br. J. Pharmacol. 141, 737 (2004), Abstract;
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel: H.H. Chuang, et al.; Neuron 43, 859 (2004), Abstract;
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH: D.A. Andersson, et al.; J. Neurosci. 24, 5364 (2004), Abstract; Full Text
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures: G.M. Story, et al.; Cell 112, 819 (2003), Abstract;
Identification of a cold receptor reveals a general role for TRP channels in thermosensation: D.D. McKemy, et al.; Nature 416, 52 (2002), Abstract;
AG-3-5: a chemical producing sensations of cold: E.T. Wei and D.A. Seid; J. Pharm. Pharmacol. 35, 110 (1983), Abstract;

Related Products

(-)-Menthol 

TRP channel activator
2216-51-5, ≥98% (sum of enantiomers, GC) | Print as PDF
 
ALX-420-042-M100 100 mg 82.00 USD
Do you need bulk/larger quantities?
 

WS-12 

TRMP8 agonist
68489-09-8, ≥98% (HPLC) | Print as PDF
 
ALX-420-041-M001 1 mg 30.00 USD
 
ALX-420-041-M005 5 mg 90.00 USD
 
ALX-420-041-M025 25 mg 310.00 USD
Do you need bulk/larger quantities?
 

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
TRP channel
By biological activity:
TRP channel Activator
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,