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Embelin

XIAP inhibitor
 
BML-CM125-0010 10 mg 74.00 USD
 
BML-CM125-0050 50 mg 297.00 USD
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Embelin is a novel cell-permeable inhibitor of XIAP (X-linked inhibitor of apoptosis) which was discovered by screening a library of natural products derived from traditional Chinese medicine. It binds to the XIAP BIR3 domain preventing its binding to and inhibition of caspase-9 and effector caspases. Embelin selectively inhibits cell growth in cancer cells expressing high levels of XIAP (IC50 = 3-6 µM) versus normal cells with low levels of XIAP.

Product Specification

Alternative Name:Embelic acid
 
Formula:C17H26O4
 
MW:294.4
 
CAS:550-24-3
 
Purity:≥98% (HPLC)
 
Appearance:Orange crystalline solid.
 
Solubility:Soluble in DMSO (10mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database: Z. Nikolovska-Coleska et al.; J. Med. Chem. 47, 2430 (2004), Abstract;

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