Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

2-Methoxy-antimycin A

Bcl-2 inhibitor
 
BML-CM123-0001 1 mg 72.00 USD
 
BML-CM123-0005 5 mg 288.00 USD
Do you need bulk/larger quantities?
 
An analog of antimycin A (mixture of antimycin A1, A2, A3 and A4) which binds to the hydrophobic groove of Bcl-2 and Bcl-XL thereby inducing apoptosis. It displays selective cytotoxicity for Bcl-XL-expressing cells (10µg/ml). Unlike antimycin A it does not exhibit general mitochondrial toxicity.

Product Specification

Formula:C27H38N2O9
 
MW:534.6
 
Purity:≥85%
 
Appearance:White solid.
 
MeltingPoint:63.5-65°C
 
Solubility:Soluble in DMSO (12 mg/ml) or ethanol (12 mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at-20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
BML-CM123 structure
2-Methoxy-antimycin A1
Please mouse over
BML-CM123 structure

Product Literature References

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell Biol. 3, 183 (2001), Abstract;
A model of antimycin A binding based on structure-activity studies of synthetic antimycin A analogues: H. Miyoshi, et al.; Biochim. Biophys. Acta 1229, 149 (1995), Abstract;
Structural factors of antimycin A molecule required for inhibitory action: N. Tokutake, et al.; Biochim. Biophys. Acta 1185, 271 (1994), Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Bcl-2
By biological activity:
Bcl-2 Inhibitor
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,