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FCCP

MPTP inhibitor
 
BML-CM120-0010 10 mg 85.00 USD
 
BML-CM120-0050 50 mg 326.00 USD
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A potent reversible inhibitor of mitochondrial oxidative phosphorylation. FCCP is a useful tool for depolarizing mitochondrial membrane potential. Treatment of cells with FCCP at varying concentrations leads to partial (100 nM) or complete (10 µM) depolarization and apoptosis.

Product Specification

Alternative Name:Carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone
 
Formula:C10H5F3N4O
 
MW:254.2
 
CAS:370-86-5
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells: I. Gautier, et al.; Neuroreport 11, 2953 (2000), Abstract;
Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization: T. J. Collins, et al.; Biochem. J. 347, 593 (2000), Abstract; Full Text
Staining of mitochondrial membranes with 10-nonyl acridine orange, MitoFluor Green, and MitoTracker Green is affected by mitochondrial membrane potential altering drugs: J. F. Keij, et al.; Cytometry 39, 203 (2000), Abstract;

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