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Citrinin

MPTP activator
 
BML-CM116-0005 5 mg 96.00 USD
 
BML-CM116-0025 25 mg 367.00 USD
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Replaces Prod. #: ALX-380-058

Antibiotic. Induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain. Mycotoxin. Acts as nephrotoxin in all species in which it has been tested. Has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans. Induces apoptosis.

Product Specification

Formula:C13H14O5
 
MW:250.2
 
Source:Isolated from Penicillium citrinum
 
CAS:518-75-2
 
Purity:≥98% (HPLC, TLC)
 
Appearance:Yellow crystalline solid.
 
Solubility:Soluble in 100% ethanol, methylene chloride (10mg/ml), methanol, dioxane, pyridine or dichlormethane. Insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9).
 
Handling:Protect from light.
 
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Product Literature References

Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts: W.H. Chan ; Biochem. J. 404, 317 (2007), Abstract;
Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway: F.Y. Yu et al.; Toxicol. Lett. 161, 143 (2006), Abstract;
Clin Microbiol Rev: J.W. Bennett & M. Klich; Clin. Microbiol. Rev. 16, 497 (2003), Abstract;
Citrinin-induced mitochondrial permeability transition: E:J. Da Lozzo et al.; J Biochem Mol Toxicol 12, 291 (1998), Abstract;
Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling: G.M. Chagas et al.; J. Appl. Toxicol. 15, 91 (1995), Abstract;

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