Replaces Prod. #: ALX-270-293
- MPTP inhibitor used in cellular metabolism studies
Decylubiquinone is an analogue of ubiquinone. Decylubiquinone inhibits the Ca2+-dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration. Maximum effect on Ca2+ retention capacity of rat liver mitochondria can be achieved with decylubiquinone at 100μM. This inhibitory effect of decylubiquinone on MPTP can be counteracted by ubiquinone-5 (Prod. No. ALX-270-294). Decylubiquinone also inhibits etoposide-induced apoptosis in in L929 cells at 5μM.
Product Details
| Alternative Name: | 2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone |
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| Formula: | C19H30O4 |
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| MW: | 322.4 |
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| CAS: | 55486-00-5 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | Neat yellow to orange colored oil. |
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| Solubility: | Soluble in DMSO (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice: T.J. Schirris, et al.; Biochim. Biophys. Acta Mol. Basis Dis.
1867, 166062 (2021),
Abstract;
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism: M.G. Acoba, et al.; Cell Rep.
34, 108869 (2021),
Abstract;
Full Text
Disruption of acetyl-lysine turnover in muscle mitochondria promotes insulin resistance and redox stress without overt respiratory dysfunction: A. Williams, et al.; Cell Metab.
31, 131 (2019),
Abstract;
Full Text
X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation: M. Jackson, et al.; Structure
27, 794 (2019),
Abstract;
Full Text
The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c: N.O. Karpinich, et al.; J. Biol. Chem.
277, 16547 (2002),
Abstract;
Full Text
A ubiquinone-binding site regulates the mitochondrial permeability transition pore: E. Fontaine, et al.; J. Biol. Chem.
273, 25734 (1998),
Abstract;
Full Text
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