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Decylubiquinone

MPTP inhibitor
 
BML-CM115-0010 10 mg 54.00 USD
 
BML-CM115-0050 50 mg 231.00 USD
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Replaces Prod. #: ALX-270-293

Inhibits the Ca2+ dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration. Maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100μM. Inhibits etoposide-induced apoptosis in in L929 cells at 5μM.

Product Specification

Alternative Name:2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
 
Formula:C19H30O4
 
MW:322.4
 
CAS:55486-00-5
 
Purity:≥97% (HPLC)
 
Appearance:Neat yellow to orange colored oil.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
BML-CM115 structure
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BML-CM115 structure

Product Literature References

The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c: N.O. Karpinich, et al.; J. Biol. Chem. 277, 16547 (2002), Abstract; Full Text
A ubiquinone-binding site regulates the mitochondrial permeability transition pore: E. Fontaine, et al.; J. Biol. Chem. 273, 25734 (1998), Abstract; Full Text

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