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Bongkrekic acid . triammonium salt

MPTP inhibitor
 
BML-CM113-0100 100 µg 138.00 USD
 
BML-CM113-1000 1 mg 1,187.00 USD
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Bongkrekic acid is an inhibitory ligand of the mitochondrial adenine nucleotide translocase. It inhibits mitochondrial permeability transition pore opening. At 50 µM it inhibits dexamethasone- apoptosis in thymocytes, preventing the PARP cleavage and DEVDase (caspase-3 like) activity normally produced by these treatments.

Product Specification

Formula:C28H38O7 * 3NH3
 
MW:537.7
 
CAS:1177154-51-6
 
Purity:≥92% (HPLC)
 
Appearance:Beige to pink lyophilized solid.
 
Reconstitution:Reconstitute to 1mg/ml with distilled water
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders: E.G. Lin-Hendel, et al.; Cell Rep. 15, 229 (2016), Abstract; Full Text
The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles: M. Ziegler et al.; J. Biol. Chem. 268, 25320 (1993), Abstract;

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