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Oligomycin A

ATPase inhibitor
 
BML-CM111-0005 5 mg 162.00 USD
 
BML-CM111-0025 25 mg 672.00 USD
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Replaces Prod. #: ALX-380-036

Inhibits mitochondrial ATPases (F1F0). Stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Induces autophagy in the IPLB-LdFB insect cell line.

Product Specification

Formula:C45H74O11
 
MW:791.1
 
CAS:579-13-5
 
MI:14: 6833
 
RTECS:RK3328000
 
Purity:≥97% (HPLC, TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (300mg/ml), 100% ethanol (200mg/ml) or acetone (800mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res. 326, 179 (2006), Abstract;
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004), Abstract;
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002), Abstract;
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000), Abstract;
Acidification of rat liver lysosomes: quantitation and comparison with endosomes: R.W. Van Dyke; Am. J. Physiol. 265, C901 (1993), Abstract;
Inhibitors of the ATP synthethase system: P.E. Linnett & R.B. Beechey; Methods Enzymol. 55, 472 (1979), Abstract;

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