Oligomycin A - Enzo Life Sciences

BML-CM111

Revised 01-Feb-10

Oligomycin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
BML-CM111-0005		5 mg	140.00 USD
BML-CM111-0025		25 mg	560.00 USD
Replaces Prod. #: ALX-380-036

Product Specification

FORMULA:	C₄₅H₇₄O₁₁
MW:	791.1
CAS NUMBER:	579-13-5
MERCK INDEX:	14: 6833
RTECS:	RK3328000
PURITY:	≥98% (TLC)
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in DMSO (300mg/ml), 100% ethanol (200mg/ml) or acetone (800mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Product Description

Inhibits mitochondrial ATPases (F₁F₀). Stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Induces autophagy in the IPLB-LdFB insect cell line.

Product Specific Literature References

Inhibitors of the ATP synthethase system: P.E. Linnett & R.B. Beechey; Methods Enzymol. 55, 472 (1979) Abstract
Acidification of rat liver lysosomes: quantitation and comparison with endosomes: R.W. Van Dyke; Am. J. Physiol. 265, C901 (1993) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002) Abstract
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract
Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res. 326, 179 (2006) Abstract

General Information