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NPPB

Cl- channel blocker
 
BML-CM100-0010 10 mg 51.00 USD
 
BML-CM100-0050 50 mg 223.00 USD
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Replaces Prod. #: ALX-550-279

A potent chloride channel blocker (IC50=0.1-100 µM depending on channel subtype and assay method). Inhibits cyclooxygenase (COX; IC50=8 µM). Evidence of mitochondrial uncoupling in mouse peritoneal macrophages, due to protonophore activity.

Product Specification

Alternative Name:5-Nitro-2-(3’-phenylpropyl-amino)benzoic acid
 
Formula:C16H16N2O4
 
MW:300.3
 
CAS:107254-86-4
 
Purity:≥98% (HPLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml; warm).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Inhibition of Regulatory Volume Decrease Enhances the Cytocidal Effect of Hypotonic Shock in Hepatocellular Carcinoma: M. Kudou, et al.; J. Cancer 7, 1524 (2016), Application(s): Cell culture, human HCC cell lines, Abstract; Full Text
The adenosine A2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells: M. Hayashi, et al.; Pflugers Arch. 468, 1171 (2016), Application(s): Cell culture, Abstract; Full Text
Different types of blockers of the intermediate-conductance outwardly rectifying chloride channel in epithelia: M. Tilmann, et al.; Pflugers Arch. 418, 556 (1991), Abstract;
Effects of NPPB (5-nitro-2-(3-phenylpropylamino)benzoic acid) on chloride transport in intestinal tissues and the T84 cell line: D.J. Keeling, et al.; Biochim. Biophys. Acta 1115, 42 (1991), Abstract;
Actions of the Cl- channel blocker NPPB on absorptive and secretory transport processes of Na+ and Cl- in rat descending colon: M. Diener & W. Rummel; Acta Physiol. Scand. 137, 215 (1989), Abstract;
Inhibition of prostaglandin E2 synthesis by a blocker of epithelial chloride channels: W. Breuer & K.L. Skorecki; Biochem. Biophys. Res. Commun. 163, 398 (1989), Abstract;
Cl(-)-channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship: P. Wangemann, et al.; Pflugers Arch. 407, S128 (1986), Abstract;

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