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Calpain I monoclonal antibody (15C10)

 
BML-CG1928-0100 100 µg 269.00 USD
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Product Specification

Alternative Name:μ-Calpain
 
Clone:15C10
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Human placenta calpain.
 
UniProt ID:P07384
 
Species reactivity:Human, Mouse, Rat
Bovine
 
Applications:ELISA, IP, WB
 
Purity Detail:Chromatographically purified.
 
Formulation:Liquid. In 20mM sodium phosphate, 150mM sodium chloride, pH 7.5, containing 50% glycerol and 3mM sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and μ-calpain (calpain I) are composed of two subunits (80 kDa and 30 kDa). Whereas the small subunit is common to both enzymes, the larger catalytic subunits are different and exhibit distinct calcium ion requirements. m-Calpain requires millimolar levels of Ca2+, and μ-calpain is active at micromolar concentrations of Ca2+. In addition to the ubiquitously expressed m- and μ-calpains, some tissue-specific calpains have been identified. The calpains appear to serve multiple physiological roles.
 

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