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L-Mimosine

Cell cycle blocker
 
BML-CC102-0500 500 mg 266.00 USD
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A rare plant amino acid that reversibly blocks the cell cycle at G1-phase. Inhibits the hydroxylation of deoxyhypusine and thus inhibits eukaryote initiation factor 5-A (eIF5-A). Inhibitor of mammalian tyrosinase and dopamine β-hydroxylase. Also chelates iron via the kojic acid metal-binding domain. Arrests DNA synthesis by inhibiting deoxyribonucleotide metabolism.

Product Specification

Formula:C8H10N2O4
 
MW:198.2
 
CAS:500-44-7
 
Purity:≥98%
 
Identity:Determined by 1H-NMR.
 
Appearance:Pink to brown powder.
 
Solubility:Soluble in 10% sodium bicarbonate (15mg/ml)
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Evaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents: M.D. Pelegrini, et al.; Asian. Pac. J. Trop. Med. 9, 652 (2016), Application(s): Cell culture, Abstract;
Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism: D. M. Gilbert et al.; J. Biol. Chem. 270, 9597 (1995), Abstract;
Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation: H. M. Hanauske-Abel et al.; Biochim. Biophys. Acta. 1221, 115 (1994), Abstract;
A general protocol for evaluating the specific effects of DNA replication inhibitors: V. Levenson et al.; Nucleic. Acids. Res. 21, 3997 (1993), Abstract;
Inhibition of two copper-containing enzymes, tyrosinase and dopamine beta-hydroxylase, by L-mimosine: H. Hashiguchi & H. Takahashi; Mo Pharmacol. 13, 362 (1977), Abstract;

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Cell Cycle - Mitosis, CDKS & Cell Cycle Signaling
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