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2-Aminopurine

p58 PITSLREbeta1 inhibitor
 
BML-CC100-0100 100 mg 78.00 USD
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A purine analog that can override multiple cell cycle checkpoints. May be used to override drug-induced cell cycle blocks. It is a selective protein kinase inhibitor that can inhibit p58 PITSLREβ1, a p34cdc2-related protein kinase, in vivo.

Product Specification

Formula:C5H5N5
 
MW:135.1
 
CAS:452-06-2
 
Purity:≥98% (HPLC)
 
Appearance:White to light yellow powder.
 
Solubility:Soluble in water (~10 mg/ml @50°C with agitation) or, DMSO (~10 mg/ml@50°C with agitation). DISSOLVES SLOWLY
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
bml-cc100
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Product Literature References

2-Aminopurine overrides a late telophase delay created by ectopic expression of the PITSLRE beta 1 protein kinase: J. Xiang, et al.; Biochem. Biophys. Res. Commun. 199, 1167 (1994), Abstract;
2-Aminopurine overrides multiple cell cycle checkpoints in BHK cells: P. R. Andreassen & R. L. Margolis; Proc. Natl. Acad. Sci. USA 89, 2272 (1992), Abstract; Full Text

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Cell Cycle - Mitosis, CDKS & Cell Cycle Signaling
Cell Cycle - Mitosis, CDKS & Cell Cycle Signaling
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