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αB-Crystallin (human) polyclonal antibody

 
BML-CA9360-0025 25 µl 108.00 USD
 
BML-CA9360-0100 100 µl 320.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 1-10 of human αB-crystallin.
 
UniProt ID:P02511
 
Species reactivity:Human
 
Applications:IHC, WB
 
Blocking Peptide:For Blocking peptide see Prod. No. BML-PP9360.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The presence of the small heat shock protein αB-crystallin in ballooned neurons, characteristic of Pick’s and Creutzfeld-Jacob disease, and in Rosenthal fibers, characteristic of Alexander’s disease, suggests a role in the aggregation and remodelling of neurofilaments in neurodegenerative disease. Both mono- and poly-ubiquitinylated conjugates of αB-crystallin have been observed in Rosenthal fibers. Phosphorylated αB-crystallin interacts with FBX4, an F-box-containing protein that is a component of the ubiquitin-protein isopeptide ligase SCF (Skp1/Cul1/F-box), implicating αB-crystallin in the ubiquitin-proteasome pathway.
 

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Heat Shock Proteins & the Cellular Stress Response Catalog
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