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Gingerol

ATPase activator
 
BML-CA422-0005 5 mg 113.00 USD
 
BML-CA422-0020 20 mg 401.00 USD
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Gingerol ([6]-gingerol), a pungent vanilloid isolated from ginger rhizomes (Zingiber officinale), is a novel and selective activator of skeletal and cardiac SR Ca2+-ATPase (EC50=4µM). It is a novel cardiotonic agent with antiplatelet activity. It induces apoptosis in HL-60 cells. Acts as an agonist at vanilloid receptors.

Product Specification

Formula:C17H26O4
 
MW:294.4
 
CAS:23513-14-6
 
Purity:≥97% (HPLC)
 
Appearance:White to pale yellow oily or waxy solid.
 
MeltingPoint:31°C
 
Solubility:Soluble in 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Stromal Interaction Molecule 1 Rescues Store-Operated Calcium Entry and Protects NG115-401L Cells Against Cell Death Induced by Endoplasmic Reticulum and Mitochondrial Oxidative Stress: C. Zhang, et al.; Neurochem. Int. 97, 137 (2016), Application(s): Cell culture, Abstract;
Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin: S.O. Kim, et al.; Biofactors 21, 27 (2004), Abstract;
Gingerols: a novel class of vanilloid receptor (VR1) agonists: V. N. Dedov, et al.; Br. J. Pharmacol. 137, 793 (2002), Abstract; Full Text
Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol: E. Lee, et al. ; Cancer Lett. 134, 163 (1998), Abstract;
Antiplatelet effect of gingerol isolated from Zingiber officinale: J. H. Guh, et al. ; J. Pharm. Pharmacol. 47, 329 (1995), Abstract;
Gingerol, a novel cardiotonic agent, activates the Ca2+-pumping ATPase in skeletal and cardiac sarcoplasmic reticulum: M. Kobayashi, et al.; Biochim. Biophys. Acta 903, 96 (1987), Abstract;

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