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BAPTA-AM

PKC activator
 
BML-CA411-0025 25 mg 186.00 USD
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Replaces Prod. #: ALX-450-014

BAPTA is a Ca2+ chelator with 105-fold greater affinity for Ca2+ than for Mg2+. BAPTA-AM is a cell-permeable derivative which is widely used as an intracellular calcium sponge. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.

Product Specification

Alternative Name:1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester
 
Formula:C34H40N2O18
 
MW:764.7
 
CAS:139890-68-9
 
Purity:≥90% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO (25mg/ml), dimethyl formamide (25mg/ml) or 100% ethanol (5mg/ml, warm)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
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Product Literature References

Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium: B. Messner, et al.; Cell Mol. Life Sci. 73, 1699 (2016), Application(s): Sensitive intracellular Ca2+ chelator, Abstract; Full Text
Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta 1853, 1879 (2015), Application(s): Cell Culture, Abstract;
Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation: C.S. Breton, et al.; Biochimie 116, 141 (2015), Application(s): Cell Culture, Abstract;
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet et al.; J. Biol. Chem. 278, 4778 (2003), Abstract;
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin: S. Jiang et al.; Exp. Cell Res. 212, 84 (1994), Abstract;
BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages: P. Dieter et al.; Biol. Chem. Hoppe Seyler 374, 171 (1993), Abstract;
Intracellular calcium chelator, BAPTA-AM, prevents cocaine-induced ventricular fibrillation: G.E. Billman ; Am. J. Physiol. 265, H1529 (1993), Abstract;
Role of calcium ion in induction of apoptosis by etoposide in human leukemia HL-60 cells: A. Yoshida et al.; Biochem. Biophys. Res. Commun. 196, 927 (1993), Abstract;
Cytosolic calcium as a second messenger for collagen-induced plsatelet responses: J.B. Smith et al.; Biochem. J. 288 , 925 (1992), Abstract;
The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA: S.M. Harrison & D.M. Bers; Biochim. Biophys. Acta 925, 133 (1987), Abstract;
Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator: R.Y. Tsien et al.; Nature 298, 478 (1982), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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