BAY K-8644

Ca²⁺ channel activator



BML-CA410-0005	5 mg	174.00 USD

Replaces Prod. #: ALX-550-213

A potent, direct acting, voltage-sensitive Ca²⁺ channel (L-type) activator. It exerts positive inotropic, vasoconstrictive and positive chronotropic activity (in vitro and in vivo) in a concentration range from 10^-9 to 10^-7 M.

Product Specification

Formula:	C₁₆H₁₅F₃N₂O₄

MW:	356.3

Purity:	≥98%

Appearance:	Yellow solid.

CAS:	93468-89-4

Solubility:	Soluble in 100% ethanol (20mg/ml), DMSO (20mg/ml) or methanol. Slightly soluble in water.

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at 0-4°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Hazard:	IRRITANT.

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Product Literature References

Calcium channel ligands: D.J. Triggle & R.A. Janis; Annu. Rev. Pharmacol. Toxicol. 27, 347 (1987), Abstract;

[3H]BAY K 8644, a 1,4-dihydropyridine Ca++ channel activator: characteristics of binding to high and low affinity sites in cardiac membranes: J.G. Sarmiento et al.; J. Pharmacol. Exp. Ther. 241, 140 (1987), Abstract;

A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent: G. Thomas et al.; Circ. Res. 56, 87 (1985), Abstract;

Effects of Bay k 8644, a dihydropyridine analog, on [3H]nitrendipine binding to canine cardiac sarcolemma and the relationship to a positive inotropic effect: P.L. Vaghy et al.; Circ. Res. 55, 549 (1984), Abstract;