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BAY K-8644

Ca2+ channel activator
 
BML-CA410-0005 5 mg 202.00 USD
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Replaces Prod. #: ALX-550-213

A potent, direct acting, voltage-sensitive Ca2+ channel (L-type) activator. It exerts positive inotropic, vasoconstrictive and positive chronotropic activity (in vitro and in vivo) in a concentration range from 10-9 to 10-7 M.

Product Specification

Formula:C16H15F3N2O4
 
MW:356.3
 
CAS:71145-03-4
 
Purity:≥98% (HPLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in 100% ethanol (20mg/ml), DMSO (20mg/ml) or methanol. Slightly soluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at 0-4°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Calcium channel ligands: D.J. Triggle & R.A. Janis; Annu. Rev. Pharmacol. Toxicol. 27, 347 (1987), Abstract;
[3H]BAY K 8644, a 1,4-dihydropyridine Ca++ channel activator: characteristics of binding to high and low affinity sites in cardiac membranes: J.G. Sarmiento et al.; J. Pharmacol. Exp. Ther. 241, 140 (1987), Abstract;
A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent: G. Thomas et al.; Circ. Res. 56, 87 (1985), Abstract;
Effects of Bay k 8644, a dihydropyridine analog, on [3H]nitrendipine binding to canine cardiac sarcolemma and the relationship to a positive inotropic effect: P.L. Vaghy et al.; Circ. Res. 55, 549 (1984), Abstract;

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