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Calmidazolium chloride

Calmodulin inhibitor
BML-CA300-0010 10 mg 123.00 USD
BML-CA300-0050 50 mg 506.00 USD
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Replaces Prod. #: ALX-430-026

Binds reversibly to calmodulin, inhibiting calmodulin-mediated enzyme activation. It inhibits the Ca2+/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=1 µM). Cell permeable. Inhibits calmodulin N-methyltransferase (Ki=65 nM). Blocks Ca2+-calmodulin binding to NOS. Inhibitor of voltage-gated  Ca2+ channels

Product Specification

Alternative Name:R24571
Purity:≥98% (HPLC)
Appearance:White powder.
Solubility:Soluble in 100% ethanol (>100mg/ml), DMSO (>100mg/ml), methanol, chloroform or propylene glycol. Almost insoluble in water.
Long Term Storage:+4°C
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Product Literature References

Neural tube closure depends on nitric oxide synthase activity: A. Nachmany et al.; J. Neurochem. 96, 247 (2006), Abstract;
Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells: E.N. Dedkova et al.; Am. J. Physiol. Cell Physiol. 286, C406 (2004), Abstract;
Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia: Z. Lacza et al.; Free. Radic. Biol. Med. 31, 1609 (2001), Abstract;
Ca2+/calmodulin-dependent and -independent down-regulation of c-myb mRNA levels in erythropoietin-responsive murine erythroleukemia cells. The role of calcineurin: A. Schaefer et al.; J. Biol. Chem. 271, 13484 (1996), Abstract;
Calmodulin N-methyltransferase. Kinetics, mechanism, and inhibitors: L.S. Wright et al.; J. Biol. Chem. 271, 12737 (1996), Abstract;
Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2: K.S. Murthy & G.M. Makhlouf; J. Biol. Chem. 269, 15977 (1994), Abstract;
The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells: J. Hu & E.E. el-Fakahany; Neuroreport 4, 198 (1993), Abstract;
Calmidazolium, a calmodulin inhibitor, inhibits endothelium-dependent relaxations resistant to nitro-L-arginine in the canine coronary artery: S. Illiano et al.; Br. J. Pharmacol. 107, 387 (1992), Abstract;
Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta: V.B. Schini & P.M. Vanhoutette; J. Pharmacol. Exp. Ther. 261, 553 (1992), Abstract;
Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in in: M. Asano et al.; J. Pharmacol. Exp. Ther. 251, 764 (1989), Abstract;
A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors: K. Gietzen et al.; Biochem. J. 207, 541 (1982), Abstract;

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