ω-Agatoxin TK

Ca²⁺ channel blocker



BML-CA250-0050	50 µg	397.00 USD

ω-Agatoxin TK is a peptide toxin from the funnel web spider Agelenopsis aperta. It is a selective blocker of the P-type Ca²⁺ channel (IC₅₀=15 nM). It also blocks a Q-type-like Ca²⁺ channel in rat hippocampal neurons with low sensitivity.

Product Specification

MW:	5273

Purity:	≥ 98% (HPLC)

Appearance:	Lyophilized solid.

Sequence:	Glu-Asp-Asn-Cys-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys-Thr-Trp-Gly-Gly-Thr-Lys-Cys-Cys-Arg-Gly-Arg-Pro-Cys-Arg-Cys-Ser-Met-Ile-Gly-Thr-Asn-Cys-Glu-Cys-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-D-Ser-Phe-Ala

CAS:	145017-83-0

Solubility:	Soluble in Water.

Long Term Storage:	-20°C

Hazard:	VERY TOXIC.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

Product Literature References

Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices: M. Kimura et al.; Neuroscience 66, 609 (1995), Abstract;

Two types of calcium channels sensitive to omega-agatoxin- TK in cultured rat hippocampal neurones: T. Teramoto et al.; Neuroreport 6, 1684 (1995), Abstract;

Omega-agatoxin-TK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, exerts blockade of P-type calcium channels in cerebellar Purkinje neurons: M. Kuwada et al.; Mol. Pharmacol. 46, 587 (1994), Abstract;