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Polygodial

TRPA1 activator
 
BML-CA242-0005 5 mg 93.00 USD
 
BML-CA242-0025 25 mg 370.00 USD
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Produced from the bark of Drymis winteri. Naturally occurring drimane sesquiterpene found in water pepper (Polygonum hydropiper) which has been used in folk medicine for a variety of indications. Potent and selective activator of TRPA1 (EC50= 400nM).

Product Specification

Alternative Name:(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
 
Formula:C15H22O2
 
MW:234.3
 
Source:Isolated from Polygonum hydropiper.
 
CAS:6754-20-7
 
Purity:≥98% (HPLC)
 
Appearance:White to off white solid or waxy solid.
 
Solubility:Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
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Product Literature References

Metamorphosis of the invasive ascidian Ciona savignyi: environmental variables and chemical exposure: P.L. Cahill, et al.; PeerJ. 4, e1739 (2016), Application(s): Cell culture, Abstract; Full Text
Antifungal activity of drimane sesquiterpenes from Drimys brasiliensis using bioassay-guided fractionation: A. Malheiros, et al.; J. Pharm. Pharm. Sci. 8, 335 (2008), Abstract;
TRPA1 mediates the noxious effects of natural sesquiterpene deterrents: J. Escalera, et al.; J. Biol. Chem. 283, 24136 (2008), Abstract;
Inhibition of the mitochondrial ATP synthesis by polygodial, a naturally occurring dialdehyde unsaturated sesquiterpene: M. V. Castelli, et al.; Biochem. Pharmacol. 70, 82 (2005), Abstract;
Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats: E. Andre, et al.; Neuropharmacology. 46, 590 (2004), Abstract;

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