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AP-18

TRPA1 blocker
 
BML-CA239-0005 5 mg 91.00 USD
 
BML-CA239-0025 25 mg 345.00 USD
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AP-18 is a novel TRPA1 channel blocker (CHO cells, IC50= 3.1µM; human and mouse cell lines, IC50= 4.5µM). It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs TRPV1. AP-18 was unable to block activation of TRPV1, TRPV2, TRPV3, TRPV4 or TRPM8 at concentrations up to 50μM. It reverses CFA-induced mechanical hyperalgesia in mice.

Product Specification

Alternative Name:4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
 
Formula:C11H12CINO
 
MW:209.7
 
CAS:55224-94-7
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml); ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
BML-CA239 structure
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BML-CA239 structure

Product Literature References

The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats: J. Asgar, et al.; Neuroscience 310, 206 (2015), Application(s): Cell Culture, Abstract;
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition: M. Petrus, et al.; Mol. Pain 3, 40 (2007), Abstract; Full Text

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