2-APB - Enzo Life Sciences

BML-CA238

Revised 01-Feb-10

2-APB Prod. # now: ALX-400-045
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Ca2+ Modulators

Product Specification

MW:	225.1
CAS NUMBER:	524-95-8
PURITY:	98%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	Ambient

Product Description

2-APB activates TRPV1, TRPV2 and TRPV3 but not TRPV4, TRPV5 and TRPV6. It blocks TRPC5 (IC₅₀=20µM), TRPC6, TRPM3 and TRPM8. It potentiates the effect of capsaicin, protons and heat on TRPV1. It was originally introduced as an IP₃ receptor blocker and subsequently as an inhibitor of store-operated Ca²⁺ entry (75 µM).

General Information