BCTC is a potent and selective inhibitor of capsaicin-induced (IC50=35 nM) and acid-induced (IC50=6 nM) VR1 activation. It displays analgesic activity in rat models of inflammatory and neuropathic pain. TRPV1 antagonist.
Product Details
| Formula: | C20H25ClN4O |
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| MW: | 372.9 |
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| CAS: | 393514-24-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Tan solid |
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| MeltingPoint: | 150-152°C |
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| Solubility: | Soluble in DMSO (20 mg/ml) or ethanol (15 mg/ml with warming). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties: K. J. Valenzano, et al.; J. Pharmacol. Exp. Ther.
306, 377 (2003),
Abstract;
Full Text
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain: J. D. Pomonis, et al.; J. Pharmacol. Exp. Ther.
306, 387 (2003),
Abstract;
Full Text
