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SK&F 96365

TRP channel blocker
 
BML-CA230-0005 5 mg 106.00 USD
 
BML-CA230-0025 25 mg 411.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-550-297

A novel, selective inhibitor of receptor-mediated calcium entry. It inhibits receptor-mediated calcium entry in stimulated platelets (IC50=8-12µM) neutrophils and endothelial cells at concentrations which do not affect internal Ca2+ release. Note, in some cells SK&F 96365 can activate a novel Ca2+ entry pathway. Blocks TRPC3 and TRPC6 activation. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Product Specification

Alternative Name:1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole . HCl, SKF-96365 . hydrochloride
 
Formula:C22H26N2O3 . HCl
 
MW:402.9
 
CAS:130495-35-1
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
MeltingPoint:117-119°C
 
Solubility:Soluble in water (30mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect: O. Tiapko, et al.; Sci. China Life Sci. 59, 802 (2016), Application(s): Measurement of intracellular Ca2+ signaling, Abstract;
Dual effects of SK&F 96365 in human leukemic HL-60 cells. Inhibition of calcium entry and activation of a novel cation influx pathway: Y.M. Leung, et al.; Biochem. Pharmacol. 51, 605 (1996), Abstract;
Vectorial Ca2+ flux from the extracellular space to the endoplasmic reticulum via a restricted cytoplasmic compartment regulates inositol 1,4,5-trisphosphate-stimulated Ca2+ release from internal stores in vascular endothelial cells: O.A. Cabello, et al.; Biochem. J. 295, 357 (1993), Abstract;
SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells: W.F. Graier, et al.; Biochem. Biophys. Res. Commun. 186, 1539 (1992), Abstract;
Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase: L.M. Blayney, et al.; Biochem. J. 273, 803 (1991), Abstract;
SK&F 96365, a receptor-mediated calcium entry inhibitor, inhibits calcium responses to endothelin-1 in NG108-15 cells: J. Chan, et al.; Biochem. Biophys. Res. Commun. 177, 1141 (1991), Abstract;
Receptor-mediated calcium influx in PC12 cells. ATP and bradykinin activate two independent pathways: C. Fasolato, et al.; J. Biol. Chem. 265, 20351 (1990), Abstract;
SK&F 96365, a novel inhibitor of receptor-mediated calcium entry: J.E. Merritt, et al.; Biochem. J. 271, 515 (1990), Abstract;

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