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Amlodipine

Ca2+ channel blocker
 
BML-CA202-0100 100 mg 68.00 USD
 
BML-CA202-1000 1 g 205.00 USD
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Amlodipine is a third generation L-type calcium channel blocker with a unique spectrum of actions, over and above its antihypertensive activity which include stimulation of NO synthase, inhibition of monocyte-endothelial adhesion, inhibition of oxidative stress and sustained duration of action.

Product Specification

Formula:C20H25ClN2O5
 
MW:408.9
 
CAS:88150-42-9
 
Purity:≥98% (Assay)
 
Appearance:Almost white crystal powder
 
Solubility:Soluble in methanol, DMSO (25mg/ml), 100% ethanol (25mg/ml), dimethyl formamide (25mg/ml) or chloroform.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

A calcium channel blocker activates both ecto-5(')-nucleotidase and NO synthase in HUVEC: Y. Asano, et al.; Biochem. Biophys. Res. Commun. 311, 625 (2003), Abstract;
Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction: T. Yu, et al.; Hypertension 42, 329 (2003), Abstract; Full Text
Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine: R. P. Mason, et al.; Arterioscler. Thromb. Vasc. Biol. 23, 2155 (2003), Abstract; Full Text
A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects: S. Ueda, et al.; Br. J. Clin. Pharmacol. 36, 561 (1993), Abstract; Full Text

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