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Antibiotic A-23187, 4-bromo

Calcium ionophore, non-fluorescent
 
BML-CA101-0001 1 mg 98.00 USD
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Replaces Prod. #: ALX-450-003

A highly selective calcium ionophore which is a useful tool for increasing intracellular Ca2+ concentration. A nonfluorescent analog of A-23187 and therefore useful in the presence of fluorescent probes.

Product Specification

Formula:C29H36BrN3O6
 
MW:602.5
 
CAS:76455-48-6
 
Purity:≥98% (TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in dichloromethane (clear colorless solution at 10 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light and moisture.
 
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Product Literature References

The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187: T. Qian, et al.; Toxicol. Appl. Pharmacol. 154, 117 (1999), Abstract;
Ionophore bromo-A23187 reveals cellular calcium stores in single pituitary somatotropes: R.W. Holl, et al.; Mol. Cell. Endocrinol. 64, 105 (1989), Abstract;
Calcium transport by ionophorous peptides in dog and human lymphocytes detected by quin-2 fluorescence: C.M. Deber & L.C. Hsu; BBRC 134, 731 (1986), Abstract;
Bromo-A23187: a nonfluorescent calcium ionophore for use with fluorescent probes: C.M. Deber, et al.; Anal. Biochem. 146, 349 (1985), Abstract;

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