Replaces Prod. #: ALX-450-001
Antibiotic possessing weak in vitro antimicrobial activity against gram positive bacteria and fungi. A highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells.
Product Details
| Formula: | C29H37N3O6 |
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| MW: | 523.6 |
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| Source: | Isolated from Streptomyces chartreusis |
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| CAS: | 52665-69-7 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO an, 100% ethanol or methylene chloride (10mg/ml); slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | In aqueous systems product may aggregate over time. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop: H. Shindou, et al.; FASEB J.
31, 2973 (2017),
Abstract;
Full Text
Disturbed B cell homeostasis in newly diagnosed giant cell arteritis and polymyalgia rheumatica: K.S. van der Geest, et al.; Arthritis Rheumatol.
66, 1927 (2014),
Abstract;
Enhanced assay of endothelial exocytosis using extracellular matrix components: M.B. LoMonaco, et al.; Anal. Biochem.
452, 19 (2014),
Abstract;
Full Text
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: T. Przygodzki et al.; Biochim. Biophys. Acta.
1740, 481 (2005),
Abstract;
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus: P.V. Rao et al.; J. Assoc. Physicians India
53, 521 (2005),
Abstract;
Molecular mechanisms of endothelium-mediated vasodilation: R.R. Fiscus et al.; Semin. Thromb. Hemost.
14 Suppl, 12 (1988),
Abstract;
A total synthesis of polyether antibiotic (-)-A23187 (calcimycin): D.P. Negri & Y. Kishi; Tetrahedron. Lett. 28, 1063 (1987),
Use of the ionophore A23187 to measure and control cytoplasmic Ca2+ levels in intact red cells: V.L. Lew & J. Garcia-Sancho; Cell. Calcium
6, 15 (1985),
Abstract;
Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem.
45, 501 (1976),
Abstract;
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria: D.T. Wong et al.; Arch. Biochem. Biophys.
156, 578 (1973),
Abstract;
A23187: a divalent cation ionophore: P.W. Reed & H.A. Lardy; J. Biol. Chem.
247, 6970 (1972),
Abstract;
