Antibiotic A-23187 (Calcimycin)

Calcium ionophore



BML-CA100-0010	10 mg	95.00 USD

Replaces Prod. #: ALX-450-001

Antibiotic possessing weak in vitro antimicrobial activity against gram positive bacteria and fungi. A highly selective divalent cation ionophore, commonly used to increase intracellular Ca²⁺ levels in intact cells.

Product Specification

Formula:	C₂₉H₃₇N₃O₆

MW:	523.6

Purity:	≥ 99% (TLC)

Appearance:	Off-white solid.

CAS:	52665-69-7

Source/Host:	Isolated from Streptomyces chartreusis

Solubility:	Soluble in DMSO an, 100% ethanol or methylene chloride (10mg/ml); slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.

Long Term Storage:	-20°C

Use/Stability:	In aqueous systems product may aggregate over time. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Hazard:	IRRITANT. TOXIC.

Handling:	Protect from light.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: T. Przygodzki et al.; Biochim. Biophys. Acta. 1740, 481 (2005), Abstract;

Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus: P.V. Rao et al.; J. Assoc. Physicians India 53, 521 (2005), Abstract;

Molecular mechanisms of endothelium-mediated vasodilation: R.R. Fiscus et al.; Semin. Thromb. Hemost. 14 Suppl, 12 (1988), Abstract;

D.P. Nergri & Y. Kishi; Tetrahedron. Lett. 28, 1063 (1987),

V.L. Lew & J. Garcia-Sancho; Cell. Calcium 6, 15 (1985),

Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem. 45, 501 (1976), Abstract;

Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria: D.T. Wong et al.; Arch. Biochem. Biophys. 156, 578 (1973), Abstract;

A23187: a divalent cation ionophore: P.W. Reed & H.A. Lardy; J. Biol. Chem. 247, 6970 (1972), Abstract;