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Antibiotic A-23187 (Calcimycin)

Calcium ionophore
 
BML-CA100-0010 10 mg 111.00 USD
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Replaces Prod. #: ALX-450-001

Antibiotic possessing weak in vitro antimicrobial activity against gram positive bacteria and fungi. A highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells.

Product Specification

Formula:C29H37N3O6
 
MW:523.6
 
Source:Isolated from Streptomyces chartreusis
 
CAS:52665-69-7
 
Purity:≥99% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO an, 100% ethanol or methylene chloride (10mg/ml); slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:In aqueous systems product may aggregate over time. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Protect from light.
 
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Product Literature References

Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: T. Przygodzki et al.; Biochim. Biophys. Acta. 1740, 481 (2005), Abstract;
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus: P.V. Rao et al.; J. Assoc. Physicians India 53, 521 (2005), Abstract;
Molecular mechanisms of endothelium-mediated vasodilation: R.R. Fiscus et al.; Semin. Thromb. Hemost. 14 Suppl, 12 (1988), Abstract;
A total synthesis of polyether antibiotic (-)-A23187 (calcimycin): D.P. Negri & Y. Kishi; Tetrahedron. Lett. 28, 1063 (1987),
Use of the ionophore A23187 to measure and control cytoplasmic Ca2+ levels in intact red cells: V.L. Lew & J. Garcia-Sancho; Cell. Calcium 6, 15 (1985), Abstract;
Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem. 45, 501 (1976), Abstract;
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria: D.T. Wong et al.; Arch. Biochem. Biophys. 156, 578 (1973), Abstract;
A23187: a divalent cation ionophore: P.W. Reed & H.A. Lardy; J. Biol. Chem. 247, 6970 (1972), Abstract;

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