BQCA

Acetylcholine receptor activator



BML-C121-0010	10 mg	88.00 USD

BML-C121-0050	50 mg	350.00 USD

Highly selective allosteric potentiator of the M₁ muscarinic acetylcholine receptor (mAChR). Reduces the concentration of ACh required to activate M₁ up to 129-fold and displays no potentiation, agonism or antagonism activity at other mAChRs at concentrations up to 100µM. Reverses scopolamine-induced memory deficits and increases blood flow to the cerebral cortex in mouse models. M₁ activators slow the progression of Alzheimers disease. Induces β-arrestin recruitment to M₁.

Alternative Name:	1-(4-Methoxybenzyl)-4-oxo-1,4-dihydro-3-quinoline carboxylic acid

Formula:	C₁₈H₁₅NO₄

MW:	309.3

Purity:	≥98% (TLC)

Appearance:	White solid.

Source/Host:	Synthetic.

Solubility:	Soluble in DMSO (10mg/ml).

Long Term Storage:	Ambient

Use/Stability:	Stable for at least 1 year after receipt when stored at room temperature. Stock solutions are stable for for up to 3 months at -20°C.

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Product Literature References

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.: L. Ma, et al.; PNAS 106, 15950 (2009), Abstract; Full Text

Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease.: A. Fisher; Neurotherapeutics 5, 433 (2008), Abstract;