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PNU-282987

Nicotinic acetylcholine receptor activator
 
BML-C120-0010 10 mg 93.00 USD
 
BML-C120-0050 50 mg 394.00 USD
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A highly selective α7 nicotinic acetylcholine receptor agonist and prototypical novel therapeutic for schizophrenia.

Product Specification

Formula:C14H17ClN2O
 
MW:264.8
 
CAS:123464-89-1
 
Purity:≥99% (TLC)
 
Appearance:White to off-white solid
 
MeltingPoint:240-242°C
 
Solubility:Soluble in DMSO (20 mg/ml), water (6 mg/ml) or ethanol (6 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to one year. Store solutions at -20°C for up to three months.
 
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Product Literature References

Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation: C.J. Siok, et al.; Eur. J. Neurosci. 23, 570 (2006), Abstract;
The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats: M. Hajos, et al.; J. Pharmacol. Exp. Ther. 312, 1213 (2005), Abstract; Full Text

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