A highly selective α7 nicotinic acetylcholine receptor agonist and prototypical novel therapeutic for schizophrenia.
Product Details
| Formula: | C14H17ClN2O |
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| MW: | 264.8 |
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| CAS: | 123464-89-1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid |
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| Solubility: | Soluble in DMSO (20 mg/ml), water (6 mg/ml) or ethanol (6 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to one year. Store solutions at -20°C for up to three months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation: C.J. Siok, et al.; Eur. J. Neurosci.
23, 570 (2006),
Abstract;
The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats: M. Hajos, et al.; J. Pharmacol. Exp. Ther.
312, 1213 (2005),
Abstract;
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