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(±)Epibatidine

Nicotinic acetylcholine receptor ligand
 
BML-C114-0005 5 mg 278.00 USD
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Epibatidine is an analgesic alkaloid isolated from the skin of the poison frog Epipedobates tricolor. It is the most potent nicotinic acetylcholine receptor agonist known. The natural (+) enantiomer is only 2-fold more potent than the (-) enantiomer with respect to analgesic activity in mice. Both enantiomers bind with high affinity (Ki=0.045 and 0.058 nM respectively) to rat brain membrane nicotinic receptors.

Product Specification

Formula:C11H13ClN2
 
MW:208.7
 
CAS:140111-52-0
 
Purity:≥99% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (5 mg/ml) or DMSO (20 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Epibatidine, a potent analgetic and nicotinic agonist: B. Badio & J.W. Daly; Mol. Pharmacol. 45, 563 (1994), Abstract;
Epibatidine is a nicotinic analgesic: C. Qian, et al.; Eur. J. Pharmacol. 250, R13 (1993), Abstract;

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