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Boc-Leu-Arg-Arg-AMC

 
BML-BW8515-0005 5 mg 109.00 USD
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A substrate for the Kex2 endopeptidase from S. cerevisiae. This peptide is also a substrate for kallikrein 5 (KLK5), and a candidate substrate for the investigation of proteasome subunit function.

Product Specification

Alternative Name:Boc-LRR-AMC
 
Sequence:Boc-LRR-AMC, Fluorogenic Substrate
 
MW:737.3
 
Purity:≥97% (HPLC)
 
Solubility:Soluble in water (50mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 

Product Literature References

Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation: W.H. Choi, et al.; Nat. Commun. 7, 10963 (2016), Application(s): Western blot, Abstract;
Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system: C. McKinnon, et al.; Acta Neuropathol. 131, 411 (2016), Application(s): Determined trypsin-like activity, Abstract; Full Text
FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing: Z. Wang, et al.; Cell Death Dis. 6, e1815 (2015), Application(s): Proteasome activity assays, Abstract; Full Text
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts: A.D. Sklirou, et al.; Redox Biol. 5, 205 (2015), Application(s): Fluorescent detection, Abstract;

General Literature References

Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression: I.P. Michael, et al.; J. Biol. Chem. 280, 14628 (2005), Abstract;

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Kallikrein
Endopeptidase
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