Highly specific inhibitor of the caspase-like peptidic activity of the 20S proteasome.
Product Details
| Sequence: | Ac-Ala-Pro-Nle-Asp-OH |
| |
| Formula: | C20H32N4O8 |
| |
| MW: | 456.5 |
| |
| Purity: | ≥95% (Reverse-Phase HPLC) |
| |
| Appearance: | Glassy lyophilized solid. |
| |
| Solubility: | Soluble in water:acetonitrile containing 0.1% TFA (3:1) at a concentration of 1mg/mL. |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Once dissolved use solutions immediately and do not store. |
| |
| Handling: | Do not add buffers containing free amino groups as these will react with the aldehyde moiety thus inactivating the compound. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.: Kisselev, A.F., Garcia-Calvo, M., Overkleeft, H.S., Peterson, E., Pennington, M.W., Ploegh, H.L., Thornberry, N.A. and Goldberg, A.L. ; J Biol. Chem. 278, 35869-35877 (2003),
