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Ada-(Ahx)3-(Leu)3-vinyl sulfone

 
BML-AW9155-0100 100 µg 140.00 USD
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A new class of proteasome inhibitors, considerably extended in comparison with the commonly used fluorescent substrates and peptide-based inhibitors, has been prepared. Evaluation of these new compounds revealed a set of highly potent proteasome inhibitors that target all individual active subunits with comparable affinity, unlike the other inhibitors described to date. These compounds are more potent in living cells than their shorter peptide vinyl sulphone counterparts. Modification of the most active compound, adamantaneacetyl-(6-aminohexanoyl)3-(leucyl)3-vinylmethyl-sulphone itself capable of proteasome inhibition in living cells, afforded a new set of radio- and affinity labels.

Product Specification

Sequence:Ada-(Ahx)3-(Leu)3-vinyl sulfone
 
Formula:C50H88N6O8S
 
MW:932.6
 
Purity:≥94% (HPLC)
 
Appearance:Off-white powder.
 
Solubility:Soluble in DMSO (<50mM).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
BML-AW9155 structure
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BML-AW9155 structure

Product Literature References

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits: B. M. Kessler et al.; Chem. Biol. 8, 913 (2001), Abstract;

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