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Carvedilol

Adrenergic receptor ligand
 
BML-AR112-0100 100 mg 63.00 USD
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An antagonist at α1- and β-adrenergic receptors. Displays antioxidant and antiapoptotic effects in vivo.

Product Specification

Alternative Name:1-(9H-Carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
 
Formula:C24H26N2O4
 
MW:406.5
 
CAS:72956-09-3
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white crystalline powder
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
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Product Literature References

The antioxidative effects of long-term treatment are more pronounced for carvedilol than for atenolol in post-myocardial infarction patients: G. Jonsson, et al.; J. Cardiovasc. Pharmacol. 49, 27 (2007), Abstract;
Effect of alpha1-adrenergic receptors in cardiac pathophysiology: R. Shannon & M. Chaudhry; Am. Heart J. 152, 842 (2006), Abstract;
Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors: T.A. Koshimizu, et al.; Cardiovasc. Res. 63, 662 (2004), Abstract;
Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers: S.A. Fahlbusch, et al.; Eur. J. Clin. Pharmacol. 60, 83 (2004), Abstract;
Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy: K. Kawai, et al.; Am. J. Physiol. Heart Circ. Physiol. 287, H1003 (2004), Abstract;

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