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Timosaponin AIII

mTOR inhibitor
 
BML-AP504-0005 5 mg 87.00 USD
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Induces autophagy in HeLa cells followed by apoptotic cell death (IC50=10μM). This cellular response has been found to be mediated via inhibition of mTORC1 and induction of ER stress (IC50 for BT474 cells=2.5µM and MDAMB231 cells=6µM). The pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.

Product Specification

Formula:C39H64O13
 
MW:740.9
 
CAS:41059-79-4
 
Purity:≥96% (HPLC)
 
Appearance:White to off white solid.
 
Solubility:Soluble in DMSO (20 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-AP504 Structure
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BML-AP504 Structure

Product Literature References

Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress: F.W. King, et al.; PLoS ONE 4, e7283 (2009), Abstract; Full Text
Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice: B. Lee, et al.; Pharmacol. Biochem. Behav. 93, 121 (2009), Abstract;
Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells: L.K. Sy, et al.; Cancer Res. 68, 10229 (2008), Abstract; Full Text

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