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Pifithrin μ

HSP70 inhibitor
 
BML-AP503-0005 5 mg 55.00 USD
 
BML-AP503-0025 25 mg 179.00 USD
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Inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation. Pifithrin-μ has also been shown to inhibit HSP70 leading to tumor cell death associated with protein aggregation, impaired autophagy and inhibition of lysosomal function.

Product Specification

Alternative Name:2-Phenylethynesulfonamide
 
Formula:C8H7NO2S
 
MW:181.2
 
CAS:64984-31-2
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (>25 mg/ml) or 100% ethanol (>25 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-AP503 Structure
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BML-AP503 Structure

Product Literature References

A small molecule inhibitor of inducible heat shock protein 70: J. Leu, et al.; Mol. Cell 15, 36 (2009), Abstract; Full Text
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation: E. Strom, et al.; Nat. Chem. Biol. 2, 474 (2006), Abstract;

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