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PI3 kinase inhibitor
BML-AP502-0025 25 mg 80.00 USD
PI3 kinase inhibitor and a well-known inhibitor of autophagy. This compound has been shown to induce autophagy under nutrient-rich conditions as well as inhibiting starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase.

Product Specification

Alternative Name:6-Amino-3-methylpurine
Purity:≥98% (TLC)
Identity:Determined by NMR.
Appearance:White solid.
Solubility:Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
Long Term Storage:-20°C
Use/Stability:Solutions can be stored at -20°C for up to 3 months.
Handling:Solutions can be stored at -20°C for up to 3 months.
BML-AP502 Structure
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BML-AP502 Structure

Product Literature References

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III of phosphoinositide 3-kinase: Y.T. Wu, et al.; J. Biol. Chem. 285, 10850 (2010), Abstract;
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem. 243, 240 (1997), Abstract;
Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine: K.B. Hendil, et al.; Biochem. J. 272, 577 (1990), Abstract; Full Text
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes: P.O. Seglen, et al. ; PNAS 79, 1889 (1982), Abstract; Full Text

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