PI3 kinase inhibitor and a well-known inhibitor of autophagy. This compound has been shown to induce autophagy under nutrient-rich conditions as well as inhibiting starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase.
Product Details
| Alternative Name: | 6-Amino-3-methylpurine |
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| Formula: | C6H7N5 |
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| MW: | 149.2 |
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| CAS: | 5142-23-4 |
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| RTECS: | AU6520000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solutions can be stored at -20°C for up to 3 months. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
New Guanidine Alkaloids Batzelladines O and P from the Marine Sponge Monanchora pulchra Induce Apoptosis and Autophagy in Prostate Cancer Cells: S.A. Dyshlovoy, et al.; Mar. Drugs
20, 738 (2022),
Abstract;
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro
6, ENEURO.0263-18.2019 (2019),
Abstract;
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Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner: C.L. Yu, et al.; Cell Death Dis.
10, 418 (2019),
Abstract;
Full Text
Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts: M. Kato, et al.; Arthritis Rheumatol.
66, 40 (2014),
Application(s): IF, WB, IHC, Flow,
Abstract;
The thiazole derivative CPTH6 impairs autophagy: Y. Ragazzoni, et al.; Cell Death Dis.
4, e524 (2013),
Application(s): IF, WB, Electron Microscopy,
Abstract;
Full Text
Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene: C. Guido, et al.; Cell Cycle
11, 2911 (2012),
Application(s): WB, ChIP & EMSA Assays,
Abstract;
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Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III of phosphoinositide 3-kinase: Y.T. Wu, et al.; J. Biol. Chem.
285, 10850 (2010),
Abstract;
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem.
243, 240 (1997),
Abstract;
Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine: K.B. Hendil, et al.; Biochem. J.
272, 577 (1990),
Abstract;
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3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes: P.O. Seglen, et al. ; PNAS
79, 1889 (1982),
Abstract;
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