Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

3-Methyladenine

PI3 kinase inhibitor
 
BML-AP502-0025 25 mg 80.00 USD
 
PI3 kinase inhibitor and a well-known inhibitor of autophagy. This compound has been shown to induce autophagy under nutrient-rich conditions as well as inhibiting starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase.

Product Specification

Alternative Name:6-Amino-3-methylpurine
 
Formula:C6H7N5
 
MW:149.2
 
CAS:5142-23-4
 
RTECS:AU6520000
 
Purity:≥98% (TLC)
 
Identity:Determined by NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
 
Long Term Storage:-20°C
 
Use/Stability:Solutions can be stored at -20°C for up to 3 months.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-AP502 Structure
Please mouse over
BML-AP502 Structure

Product Literature References

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III of phosphoinositide 3-kinase: Y.T. Wu, et al.; J. Biol. Chem. 285, 10850 (2010), Abstract;
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem. 243, 240 (1997), Abstract;
Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine: K.B. Hendil, et al.; Biochem. J. 272, 577 (1990), Abstract; Full Text
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes: P.O. Seglen, et al. ; PNAS 79, 1889 (1982), Abstract; Full Text

Related Literature

Product Flyers
Comprehensive Solutions for Autophagy
Comprehensive Solutions for Autophagy 07-Nov-11
Download as PDF

All new literature pieces

Recommend this page

 
Keep in touch

©2014 Enzo Life Sciences, Inc.,