3-Methyladenine

PI3 kinase inhibitor



BML-AP502-0025	25 mg	77.00 USD

PI3 kinase inhibitor and a well-known inhibitor of autophagy. This compound has been shown to induce autophagy under nutrient-rich conditions as well as inhibiting starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase.

Product Specification

Alternative Name:	6-Amino-3-methylpurine

Formula:	C₆H₇N₅

MW:	149.2

CAS:	5142-23-4

RTECS:	AU6520000

Purity:	≥98% (TLC)

Appearance:	White solid.

Solubility:	Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).

Long Term Storage:	-20°C

Handling:	Solutions can be stored at -20°C for up to 3 months.

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Product Literature References

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III of phosphoinositide 3-kinase: Y.T. Wu, et al.; J. Biol. Chem. 285, 10850 (2010), Abstract;

The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem. 243, 240 (1997), Abstract;

Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine: K.B. Hendil, et al.; Biochem. J. 272, 577 (1990), Abstract; Full Text

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes: P.O. Seglen, et al. ; PNAS 79, 1889 (1982), Abstract; Full Text