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3-Methyladenine

PI3 kinase inhibitor
 
BML-AP502-0025 25 mg 80.00 USD
 
PI3 kinase inhibitor and a well-known inhibitor of autophagy. This compound has been shown to induce autophagy under nutrient-rich conditions as well as inhibiting starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase.

Product Specification

Alternative Name:6-Amino-3-methylpurine
 
Formula:C6H7N5
 
MW:149.2
 
CAS:5142-23-4
 
RTECS:AU6520000
 
Purity:≥98% (TLC)
 
Identity:Determined by NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
 
Long Term Storage:-20°C
 
Use/Stability:Solutions can be stored at -20°C for up to 3 months.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-AP502 Structure
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BML-AP502 Structure

Product Literature References

Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts: M. Kato, et al.; Arthritis Rheumatol. 66, 40 (2014), Application(s): IF, WB, IHC, Flow, Abstract;
The thiazole derivative CPTH6 impairs autophagy: Y. Ragazzoni, et al.; Cell Death Dis. 4, 524 (2013), Application(s): IF, WB, Electron Microscopy, Abstract; Full Text
Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene: C. Guido, et al.; Cell Cycle 11, 2911 (2012), Application(s): WB, ChIP & EMSA Assays, Abstract; Full Text
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III of phosphoinositide 3-kinase: Y.T. Wu, et al.; J. Biol. Chem. 285, 10850 (2010), Abstract;
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem. 243, 240 (1997), Abstract;
Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine: K.B. Hendil, et al.; Biochem. J. 272, 577 (1990), Abstract; Full Text
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes: P.O. Seglen, et al. ; PNAS 79, 1889 (1982), Abstract; Full Text

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