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C1

Induces autophagy in tumor, but not normal, cells
 
BML-AP500-0025 25 mg 211.00 USD
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Induces simultaneous non-canonical (Beclin-1 independent) autophagy and apoptosis in human tumor cells, but not non-transformed cells. Triggers intracellular hydrogen peroxide productions leading to upstream activation of ERK and JNK.

Product Specification

Alternative Name:1,3-Dibutyl-2-thiooxoimidazolidine-4,5-dione
 
Formula:C11H18N2O2S
 
MW:242.3
 
Source:Synthetic.
 
CAS:143413-73-4
 
Purity:≥98% (TLC)
 
Appearance:Yellow oil.
 
Solubility:Soluble in DMSO (>25 mg/ml) or in 100% ethanol (>25 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Solutions can be stored at -20°C for up to 3 months.
 
BML-AP500 Structure
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BML-AP500 Structure

Product Literature References

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation: C.H. Wong, et al.; PLOS ONE 5, e9996 (2010), Abstract; Full Text

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