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Inhibits necroptosis
BML-AP309-0020 20 mg 86.00 USD
BML-AP309-0100 100 mg 337.00 USD
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Replaces Prod. #: ALX-430-136

Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Inhibits the loss of mitochondrial membrane potential in TNFα-treated Jurkat cells (EC50=490 nM). Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. It displays a pronounced protective effect in a mouse model of ischemic brain injury and inhibits myocardial cell death. Inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).

Product Specification

Alternative Name:Methylthiohydantoin-DL-tryptophan
Purity:≥98% (TLC)
Appearance:Yellow solid.
Solubility:Soluble in DMSO (20mg/ml) or 100% ethanol (5mg/ml).
Long Term Storage:Ambient
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
Handling:Protect from light.
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Product Literature References

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death: K. Moriwaki, et al.; Cell Death Dis. 6, e1636 (2015), Application(s): Cell Culture, Abstract; Full Text
Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB: M. Oliver Metzig, et al.; Oncogene (2015), Application(s): Cell culture , Abstract;
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells: P. Wu, et al.; Biochem. Biophys. Res. Commun. 460, 183 (2015), Application(s): Cell Culture, Abstract;
Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage: K. Kitur, et al.; PLoS Pathog. 11, e1004820 (2015), Application(s): Cell Culture, Abstract; Full Text
ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly: T. Selmi, et al.; BMC Cancer 15, 357 (2015), Application(s): Cell Culture, Abstract; Full Text
A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis: G. Kung, et al.; Cell Death Differ. 21, 634 (2014), Abstract;
TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis: I. Karl, et al.; Cell Death Dis. 5, e1444 (2014), Abstract; Full Text
The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB: A. Fontanini et al.; J. Biol. Chem. 284, 8369 (2009), Abstract;
Identification of RIP1 kinase as a specific cellular target of necrostatins: A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008), Abstract;
Chemical genetic approaches to probing cell death: B.R. Stockwell & N.M. Gangadhar; Curr. Opin. Chem. Biol. 11, 83 (2007), Abstract;
Clinical aspects of indoleamine 2,3-dioxygenase (IDO)-initiated tryptophan metabolism: IDO is a target of drug discovery for various diseasea: O. Takikawa; Int. Congr. Ser. 1304, 290 (2007),
Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells: X. Xu et al.; J. Neurochem. 103, 2004 (2007), Abstract;
Necrostatin: a potentially novel cardioprotective agent?: C.C. Smith et al.; Cardiovasc. Drugs Ther. 21, 227 (2007), Abstract;
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury: A. Degterev, et al.; Nat. Chem. Biol. 1, 112 (2005), Abstract;
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy: A.J. Muller et al.; Nat. Med. 11, 312 (2005), Abstract;

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