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2,3-DCPE . HCl

Bcl-X inhibitor
 
BML-AP306-0025 25 mg 288.00 USD
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2,3-DCPE induces apoptosis in several tumor cell lines (IC50=0.89 - 2.69 µM) via attenuation of Bcl-XL expression but does not induce apoptosis in normal human fibroblasts. It induces S-phase arrest and upregulates p21.

Product Specification

Formula:C11H15Cl2NO2.HCl
 
MW:300.6
 
CAS:418788-90-6
 
Purity:≥99% (HPLC)
 
Identity:Determined by 1H-NMR and 13C-NMR.
 
Appearance:White solid.
 
Solubility:Soluble in water or PBS.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol: S. Wu, et al.; Cancer Res. 64, 1110 (2004), Abstract; Full Text
Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK: H. Zhu, et al.; Oncogene 23, 4984 (2004), Abstract;

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