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Gambogic acid

Bcl-2 inhibitor, Bax activator
 
BML-AP305-0005 5 mg 83.00 USD
 
BML-AP305-0025 25 mg 332.00 USD
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Gambogic Acid is a natural product isolated from Garcinia Hurburyi. It induces apoptosis in several tumor cell lines including T47D breast cancer cells and MGC-803 human gastric carcinoma cells but not in normal cells. Apoptosis induction proceeds via upregulation of bax and inhibition of bcl-2 expression.The target of gambogic acid has been identified as the transferrin receptor.

Product Specification

Formula:C38H44O8
 
MW:628.8
 
CAS:2752-65-0
 
Purity:≥95% (TLC)
 
Appearance:Yellow-orange solid
 
Solubility:Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid: S. Kasibhatla, et al. ; Proc. Natl. Acad. Sci. 102, 12095 (2005), Abstract; Full Text
Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay: H.-Z. Zhang, et al.; Bioorg. Med. Chem. 12, 309 (2004), Abstract;
Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells: L. Zhao, et al. ; Biol. Pharm. Bull. 27, 998 (2004), Abstract;

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