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Bleomycin sulfate

Antitumor antibiotic
 
BML-AP302-0010 10 mg 281.00 USD
 
BML-AP302-0050 50 mg 989.00 USD
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Replaces Prod. #: ALX-630-107

Anti-tumor agent. Induces apoptosis via DNA damage. Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism. Inhibits intracellular DNA replication. DNA alkylating agent.

Product Specification

Alternative Name:Blenoxane
 
Formula:C55H85N17O25S4
 
MW:1512.6
 
CAS:9041-93-4
 
MI:14: 1318
 
RTECS:EC5991990
 
Purity:≥98% (HPLC)
 
Identity:Determined by IR.
 
Appearance:White crystalline solid.
 
Solubility:Soluble in water (20mg/ml) or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer: S. Duffy, et al.; PNAS 113, 9967 (2016), Application(s): Sensitivity to Genotoxic Agents, Yeast strains carrying each dCIN candidate , Abstract; Full Text
Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury: D. Shah, et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 306, L152 (2014), Abstract; Full Text
Targeting Her-2+ breast cancer cells with bleomycin immunoliposomes linked to LLO: M. Kullberg, et al.; Mol. Pharm. 9, 2000 (2012), Abstract;
Bleomycin-induced alterations in DNA replication: relationship to DNA damage: J. Dziegielewski, et al.; Biochemistry 40, 704 (2001), Abstract;
Bleomycin: new perspectives on the mechanism of action: S.M. Hecht; J. Nat. Prod. 63, 158 (2000), Abstract;
Synergistic effects of laserthermia and bleomycinsulfate on micronuclei formation in cytokinesis-blocked HeLa cells: A.S. Monfared & H. Mozdarani; Irn. J. Med. Sci. 24, 87 (1999),
Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models: M. Schirner, et al.; Clin. Cancer Res. 4, 1331 (1998), Abstract;
Changes in c-Jun but not Bcl-2 family proteins in p53-dependent apoptosis of mouse cerebellar granule neurons induced by DNA damaging agent bleomycin: T. Araki, et al.; Brain Res. 794, 239 (1998), Abstract;
Induction of apoptosis by bleomycin in resting and cycling human lymphocytes: P. Vernole, et al.; Mutagenesis 13, 209 (1998), Abstract;
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs: M. Muller, et al.; J. Exp. Med. 188, 2033 (1998), Abstract;
Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens: J.G. Christensen, et al.; Cell Growth Differ. 9, 815 (1998), Abstract;
Sequence-specific changes in the metal site of ferric bleomycin induced by the binding of DNA: J.W. Sam, et al.; J. Biol. Chem. 273, 16090 (1998), Abstract;
Cleavage of tRNA by Fe(II)-bleomycin: A. Huttenhofer, et al.; J. Biol. Chem. 267, 24471 (1992), Abstract;
Chromatin structure during bleomycin-induced DNA damage and repair: B.P. Cuiffo, et al.; J. Free Radic. Biol. Med. 1, 139 (1985), Abstract;
Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin: J. Kross, et al.; Biochemistry 21, 4310 (1982), Abstract;
Bleomycin and other antitumor antibiotics of high molecular weight: H. Umezawa; Antimicrob. Agents Chemother. (Bethesda) 5, 1079 (1965), Abstract;

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