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1,5-Isoquinolinediol

PARP inhibitor
 
BML-AP102-0020 20 mg 61.00 USD
 
BML-AP102-0100 100 mg 262.00 USD
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Replaces Prod. #: ALX-480-039

Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II) in mouse macrophages. Potent and selective PARP inhibitor. Inhibits nitric oxide (SIN-1) induced PARP activation in rat hepatocytes (at 20µM). Neuroprotectant.

Product Specification

Formula:C9H7NO2
 
MW:161.2
 
CAS:5154-02-9
 
Purity:≥98% (HPLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml), dimethyl formamide (25mg/ml) or 100% ethanol (25mg/ml warm). Also soluble in 0.1N NaOH or in methanol; insoluble in water and 0.1N HCl.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Protect from light.
 
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Product Literature References

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors 9, 173 (2016), Application(s): Potency of inhibitors, Abstract; Full Text
Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients: K. Obermeier, et al.; Oncogene 35, 3796 (2016), Abstract;
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract;
Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006), Abstract;
All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor: D.M. Berry, et al.; Leuk. Res. 24, 307 (2000), Abstract;
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol. 128, 1339 (1999), Abstract;
Inhibition of poly(ADP-ribose)polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts: A. Semionov, et al.; Nucleic Acids Res. 27, 4526 (1999), Abstract;
Nitric oxide inhibits DNA synthesis and induces activation of poly(ADP-ribose) polymerase in cultured rat hepatocytes: M. Dalmau, et al.; Exp. Cell Res. 228, 14 (1996), Abstract;
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994), Abstract;
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992), Abstract;

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The PARP Family & ADP Ribosylation
The PARP Family & ADP Ribosylation
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